Kuersetin dari Daun Erythrina poeppigiana (leguminosae)

Tati Herlina, Unang Supratman

Abstract


Erythrina plants known plants “dadap” is a higher plant that grows in tropical and subtropical regions. E. poeppigiana plants was a source of secondary metabolites, which contain flavonoids. This study aims to isolate the flavonoid compounds from the leaves of  E. poeppigiana through the stages of extraction, fraction, separation and purification. E. poeppigiana leaves powder (2.5 kg) was extracted with methanol and partitioned with n-hexane and ethyl acetate. Furthermore, the separation of ethyl acetate of E. poeppigiana leaves fraction using a combination of column chromatographic was obtained pure compound (5 mg) in the form of a yellow amorphous  solid. The chemical structure of pure compound was based on the data spectroscopy (MS, UV, IR, 1H-NMR and 13C-NMR) and identified as the compound 3,3 ‘, 4’, 5,7-pentahidroksiflavon or known as quercetin.


Keywords


Erythrina poeppigiana, flavonoid, quercetin

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References


Djiogue, S., Halabalaki, M., Alexi, X., Njamen, D., Fomum, Z.T., Alexis, M.N & Skaltsounis, A.L. 2009. Isoflavonoids from E. poeppigiana: evaluation of their binding affinity for the estrogen receptor. J Nat Prod 72(9): 1603–1607.

Golmaz, J.G., Quintremil, S & Rodrigo, R. 2015. Cardiovascular Disease: Target for the Pharmacological effects of Quercetin. Curr. Top Med Chem 15(17): 1735–1742.

Hasnirwan, Ibrahim, S & Yanti, M. 2013. Isolasi dan karakterisasi flavonoid pada fraksi aktif antioksidan dari daging buah mahkota dewa (Phaleria macrocarpa (Scheff) Boerl). Open Journal System, Prosiding Semirata FMIPA Universitas Lampung 1(1): 1–6.

Hikita, K., Tanaka, H., Murata, T., Kato, K., Hirata, Miyuki., Sakai, T & Kaneda, N. 2014. Phenolic constituen from stem bark of E. poeppigiana and their inhibitory activity on human glyoxalase I. Journal of Natural Medicines 68(3): 636 - 642.

Hikita, K., Yamada, S., Shibata, R., Katoh, M., Murata, T., Tanaka, H & Kaneda, N. 2015. Inhibitory Effect of Isoflavones from Erythrina poeppigiana on the Growth of HL-60 Human Leukemia Cell through Inhibition of Glyoxalase I. Nat Prod. Commun. 10(9): 1581 - 1584

.

Hussain, M.M., Tuhin, M.T.H., Akter, F & Rashid, M.A. 2016. Constituents of Erythrina-a Potential Source of Secondary Metabolites: A Review. Bangladesh Pharmaceutical Journal 19(2): 237–253.

Li, F.Y., Wei, H.Y., Chi, I.C., Sin, J.L & Chih, C.H. 2013. Concurrent accumulation of myrecetin and gallic acid putatively responsible for the umami taste of a specialized old long tea. Journal of food and nutrition research 1(6): 164–173.

Mardianingrum, R., Herlina, T & Supratman, U. 2015. Isolasi dan Molecular docking senyawa 6,7-dihidro-17-hidroksierisotrin dari daun dadap belendung (Erythrina poppigiana) terhadap aktivitas sitotoksik antikanker payudara MCF-7. Chimica et Natura Acta 3(3): 90–93.

Masyhud. 2010. Tanaman Obat Indonesia. http://www.dephut. go.id/indexphp? =id /node/54 (06 Mei 2016).




DOI: http://dx.doi.org/10.31258/jni.17.1.1-4

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