Diferensiasi Stadium Takizoit-Bradizoit pada Toxoplasma gondii

Abstract

Toxoplasma gondii is an intracellular parasite whose definite host is cat or felidae and intermediate host is human or
other mammals. It causes congenital and acquisita toxoplasmosis. Infection with this apicomplexan parasite results in
its dissemination throughout its host via the tachyzoite life stage. After dissemination, these tachyzoites differentiate
into bradyzoites within cyst and remain latent. These bradyzoites can transform back into tachyzoites and in
immunosupressed individuals this often results in symptomatic disease. Both tachyzoites and bradyzoites develop in
tissue culture and this crucial differentiation event can be studied. Interferon gamma (IFN ) is the main mediator in
tachyzoite-bradyzoite differentiation.