Resistensi Aedes aegypti terhadap Insektisida Golongan Organofosfat

Abstract

Dengue haemorrhagic fever (DHF) is one of Indonesian public health problems because of its high incidence rate.
DHF control is emphasized on vector control Aedes aegypti by using insecticide. Organophosphate has been used as
insecticides to control the dengue vectors for more than 25 years ago. The using of insecticide in long time and
sublethal dose can induce insecticide resistance. Aedes aegypti resistance of organophophate have occured based on
fisiologic and genetical mechanisms. The major mechanism of resistance to organophosphate insecticides in Aedes
aegypti is genetical mechanism. The two major forms of genetical resistance are target site resistance which occurs
when the insecticide no longer binds to its target and detoxification enzyme based resistance through highly active
non specific esterase enzyme.