Organisasi Genom dan Varian Molekuler Human PapillomavirusTipe 16 Sebagai Penyebab Karsinoma Serviks

Abstract

Human papillomaviruses (HPVs) play a central role in the etiology of cervical neoplasia. Different studies have indicatedthat viral persistence and the development of high – grade lesions and invasive carcinoma are closely associated withthe presence of HPV 16 and in some studies with specific HPV 16 variants. Sequence analysis of the HPV 16 E6, L1,L2 and URR demonstrated that HPV 16 variants form five major phylogenetic clusters, the distribution of which variesgeographically. These are classified as European (E), Asian (As), Asian-American (AA), African -1 (Af1) and African-2 (Af2). Some naturally occurring variants have different biological and biochemical properties that they may alsodiffer in pathogenicity. The data of HPV variants will have relevant to the biology of HPV infection and its associationwith squamous neoplasia and also to use of HPV typing in clinical practice.