Sintesis Beberapa Senyawa Analog Calkon menggunakan Katalis SOCl2 dan Uji Aktivitas sebagai Antimikroba

Abstract

Some chalcone analogous have been synthesized from 3’-hydroxyacetophenoneand benzaldehyde derivates by Claisen-Schmidt condensation using thyonyl chlo-ride (SOCl2) catalyst. It produced three compounds i.e. 1-(3-hydroxy-phenyl)-3-(4-hydroxy-phenyl)-prophenone; 1-(3-hydroxy-phenyl)-3-(4-chloro-phenyl) prophe-none and 1-(3- hydroxy-phenyl)-3-(4-nitro- phenyl)-prophenone. The structure ofthe compounds were then characterized using UV, IR and NMR. All of the synthe-sized compounds show antimicrobial activities toward Psedomonas aeruginosa,Bacillus subtilis and Candida albicans.