Pemulihan Kerusakan Jaringan Hati Mencit yang Diberi Ekstrak Butanol Buah Tua Mahkota Dewa

Arif Soeksmanto

Abstract


Mahkota dewa (Phaleria macrocarpa [Scheff.] Boerl.) is an Indonesians traditional medicinal plant used to treat various diseases, such as diabetes mellitus, hemorrhoid, impotency and cancer. Almost all parts of the plants can
be used as traditional medicine, but if directly consumed, it can cause swollen, sprue, numb at tongue, fever, even unconsciousness. This research was carried out to find out recovery of liver tissue damage of mice administered intraperitoneally with subchronic dosage of butanol extract 170 mg/kg body weight. Observation on first week showed that there is light degeneration (vacuolization) which is getting better on second week and apparently
normal on forth week.


Keywords


liver, mahkota dewa, Phaleria macrocarpa, vacuolization.

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References


Aldridge, W.N. 1993. The biochemical principles of toxicology. Di dalam: Anderson, D. & Conning, D.M. (eds). Experimental Toxicology; The Basic Issue. 2nd edition. Bodmin: Hartnoll Ltd. h. 56-81

Anni, S., Nurmawan, D., Alfiani, F., Hertiani, T. 2003. Daya antioksidan dan kadar flavonoid hasil estrak etanol-air daging buah mahkota dewa (Phaleria macrocarpa (Scheff.) Boerl.). Buletin Penalaran Mahasiwa UGM.

Arias, I., Popper, H., Schaefer, D., & Shafritz, D.A. 1982. The Liver, Biology and Patho- Biology. New York: Reven Press.

Burkill, I.H. 1966. A Dictionary of the Economic Products of the Malay Penninsula. Vol. II. Kuala Lumpur: Ministry of Agriculture and Co-operatives. h. 1732.

De Padua, L.S., Bunyapraphatsara, N. & Lemmens, R.H.M.S. 1999. Plant Resources of South East Asia. Medical and Poisonous Plants. Leiden, the Netherlands, Printed in Bogor Indonesia (PROSEA): Backhuys Publishers. h. 36.

Donninger, C. 1971. Species specificity of phosphate trimester anticholin-esterase. Bull. WHO 44: 265.

Eisai Indonesia. 1986. Index Tumbuh-Tumbuhan Obat Indonesia. P.T. Eisai Indonesia. h. 84.

Evans, J.G. & W.H. Butler. 1993 Histopathology in Safety Evaluation. Anderson, D. & Conning, D.M. (eds). Experimental Toxicology; The Basic Issue, 2nd edition. Bodmin: Hartnoll Ltd. h. 119.

Gotawa, I.B.I., Sugiarto, S., Nurhadi, M., Widiyastuti, Y., Wahyono, S., Prapti, I.J. 1999. Inventaris Tanaman Obat Indonesia. Jilid V. Jakarta: Departemen Kes. Badan Penelitian dan Pengembangan Kesehatan. h. 147-148.

Hardy, R.M. 1983. Disease of the liver. Di dalam: Ettinger, S.J. (ed). Textbook of Veterinary Internal Medicine, Vol. 2. Philadelphia: W.B. Saunders Co. h. 1372.

Harmanto, N. 2002. Sehat Dengan Ramuan Tradisional Mahkota Dewa. Cetakan ke empat. Tangerang: PT. Agromedia Pustaka. Harmanto, N. 2003. Conquering Disease in Unison with Mahkota Dewa (Phaleria macrocarpa). First editon. Jakarta: P.T.Mahkotadewa Indonesiah.

Huxtable, C.R.R. 1988. The urinary system. Di dalam: Robinson, W.F. & Huxtable, C.R.R. (eds). Clinicopathologic Principles for Veterinary Medicine. First Published. Cambridge University Press. h. 216.

Kelly, W.R. 1985. The liver. Di dalam: Jubb, K.V.F., Kennedy, P.C. & Palmer, N. (eds). Pathology of Domestic Animals. 3rd edition. Orlando: Academic Press. h. 239.

Rappaport, M.A. 1963. Acinar units and the physiopathology of the liver. In: The Liver Morphology, Biochemistry, Physiology, Vol. I. Ch. Rouiller (ed). New York: Academic Press. p. 265.

Rappaport, M.A. 1973. The microcirculatory hepatic unit. Microvascular Research 6: 212–218.

Sani, Y., Bustami, S., & Girindra, A. 1998. Hepatotoksisitas ekstrak daun babadotan (Ageratum conyzoides) pada tikus percobaan. J. Ilmu Ternak & Veteriner 3(1): 63.

Sulistiyani, Sofianti, D., & Purwakusumah, E.D. 2006. Khasiat antioksidan ekstrak daun mahkota dewa (Phaleria macrocarpa (Scheff.) Boerl.) pada umur yang berbeda. Prosiding Seminar Nasional Tumbuhan Obat Indonesia XXIX. Fakultas Kedokteran Universitas Sebelas Maret Surakarta, Solo, 24-25 Maret 2006.

Sumastuti, R. & Sonlimar, M. 2002. Efek sitotoksik ekstrak buah dan daun mahkota dewa [Phaleria macrocarpa (Scheff) Boerl.] terhadap sel Hela. Medika. No 12: 773-777.

Zakim, O. 1985. Pathophysiology of liver disease. Di dalam: Smith, L.M. & Their, S.O. (eds). Pathophysiology: The Biological Principles of Disease. 2nd edition. Philadelphia: W.B. Saunders Co. h. 799.




DOI: http://dx.doi.org/10.31258/jni.10.1.53-57

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