Uji Toksisitas Akut Ekstrak Air Tanaman Sarang Semut (Myrmecodia pendans) Terhadap Histologi Organ Hati Mencit

Arif Soeksmanto, Partomuan Simanjuntak, Muhammad Ahkam Subroto

Abstract


erbal products in powder or capsule forms made of sarang semut plant have been widely distributed in market.This plant is believed to treat several diseases, such as cancer, gout, liver, stroke, heart, hemorrhoid, back pain,allergy, and as tonicum to increase sexual desire. Information on the plants was still limited on plant distribution,ecology, ethnobotany, and taxonomy, without research on toxicity and clinical aspect. Considering that sarangsemut products has been distributed at market and limited scientific publication of the plant, hence acute toxicitytest of sarang semut extract should be conducted. The results showed that dose of 375 mg/kg bw caused liverdegeneration on day-5 and normal on day-19. Whereas dose of 3750 mg/kg bw caused cell necrosis up to day-12,degeneration still apparent on day-26.

Keywords


Hepatic necrosis, histology, Myrmecodia pendens, sarang semut, toxicity test

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References


Arias, I, Popper, H. Schaefer, D. & Shafritz, D. A. 1982. The Liver, Biology and Patho-Biology. New York. Reven Press,

Anonim. (2000), Pedoman Pelaksanaan Uji Klinik Obat Tradisional, DepKes RI, DitJen POM. Direktorat Pengawasan Obat Tradisional, Jakarta.

Eisenberg, D.M., Kessler, R.C., Foster, C., Norlock, F,E., Calkins, D.R. & Delbanco, T.L. (1993). Unconventional medicine in the United States - prevalence, costs, and patterns of use. N. Engl. J. Med. 328: 246-25.

Evans, J.G. & W.H. Butler. 1993 :Histopathology in Safty Evaluation. Dalam : Expe- rimental Toxicology. The Basic Issues. 2nd edition. D. Anderson and D.M. Conning (eds). Hartnolls Ltd., Bodmin.

Hardy, R.M. 1983. Diseas of the Liver. Dalam : Textbook of veterinary Internal Medicine, Vol. 2, S. J. Ettinger (ed), W. B. Saunders Co., Philadelhia.

Harun N. & Syari, W. 2002. Aktivitas antioksidan ekstrak daun dewa dalam menghambat sifat hepatotoksik halotan dengan dosis sub anastesi pada mencit. Jurnal Sains dan Teknologi Farmasi 7(2): 63-70.

Huxley, C.R. 1993. The tuberosus epiphytes of the rubiaceae 6: A taxonomic history of the hydnophytinae. Blumea 37: 335- 340.

Huxtable, C.R.R. 1988. The Urinary System. Dalam : Clinicopathologic Principles for Veterinary Medicine. First Published, W.F.Robinson & C.R.R. Huxtable (eds), Cambridge University Press, New York.

Kaplowitz, N. 2002. Biochemical and cellular mechanisms of toxic liver injury. Semin. Liver. Dis. 22: 137-144.

Kelly, W.R. 1985. The Liver. Dalam : Pathology o f Domestic Animals, 3rd edition. K. V. F. Jubb, P. C. Kennedy dan N. Palmer (eds), Academic Press, Orlando.

Mitra, S.K., Venkataraganna, M.V., Sundaran, R. & Gopumadhavan, S. 1998. Protective effect of HD-03 (1998). Protective effect of HD-03, a herbal formulation against various hepatotoxic agents in rats. J. Ethno. Pharmacol. 63:181-6.

Subroto, M.A. & Saputro, H. 2006. Gempur penyakit dengan sarang semut.Cetakan pertama, Penebar Swadaya Trubus no 438 edisi XXXVII (Mei 2006)

Wilkinson, G.R. 2005. Drug metabolism and variability among patients in drug response. N. Engl. J. Med. 352: 2211-2221.

Zakim, O. 1985. Pathophysiology of liver disease. Dalam : Pathophysiology : The Bio- logical Principles of Disease. 2nd edition. L.M. Smith & S.O. Their (eds), W.B. Saunders Co. Philadelphia.




DOI: http://dx.doi.org/10.31258/jni.12.02.%25p

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