Pencegahan Lesi Aterosklerosis Oleh Asam Alfa Lipoat Pada Aorta Mencit Jantan (Mus Musculus) Yang Diberi Diet Tinggi Kolesterol

Abstract

Atherosclerosis can happen easily on animal that are given high cholesterol diet. Alpha lipoic acid is universal antioxidant
that very effective to reduce free radicals, include lipid peroxide. The goal of this research was to find out the prohibition
of atherosclerosis lesion development on male mice aorta that was given high cholesterol diet by alpha lipoic acid. This
was an experimental laboratory research with post test only design. Eighteen adult male mice were segregated into
three groups labelled as group NaCl 0,9%, yolks and ALA.. The experiment was design for 6 weeks. The measured
parameter was atherosclerosis lesion score of groups labelled. The statistical test result showed the significant difference
of some tested groups. There was a statistically significant difference between alpha lipoic acid and yolks group (p=0,008),
but there is no significant difference was found between ALA and NaCl 0,9% group (p=0,126). As the conclusion, this
study proves that alpha lipoic acid has the effects to prohibition of atherosclerosis lesion development on male mice
aorta that are given high cholesterol diet.