Gambaran Histopatologi Kerusakan Hati Mencit yang Diproteksidengan Air Rebusan Daun Sirih (Piper Betle Linn)

Abstract

Sirih was used as traditional medicine by Indonesian. The objective of this study was to evaluate the hepatoprotectoreffect of sirih by histopathological examination. It was an experimental study with completely randomized designthrough histopathology examination on mice that was induced by paracetamol. The mice were devided into 5 groups(N=5). Group I received pellet and aquadest, group II was given 500 mg/kgBW paracetamol, group III, IV, and V wasgiven 500 mg/kgBW paracetamol combine with 20%, 40%, and 80% (w/v) of sirih, respectively. The degree of necrosiswas examined by counting centrilobular necrosis score. Data was analized using Kruskal Wallis test, continued withMann Whitney. The study shows that there was a significant difference between negative control with another groups,and also significant difference in degree of necrosis between positive control and 20%, 40% and 80% of sirih (p<0,05).As the conclusion, sirih has hepatoprotector effect on mice.